LLY
Eli Lilly and Company
LLY has the edge over VRTX overall, supported by stronger modeled upside and stronger valuation.
VRTX
Vertex Pharmaceuticals Incorporated
VRTX trails on the overall score without a compensating advantage in the available component scores.
LLY Fundamentals
| Metric | Status |
|---|---|
| Healthy | |
| Strong | |
| Strong | |
| Healthy |
LLY's revenue, profitability, cash flow and balance sheet are all currently healthy.
VRTX Fundamentals
| Metric | Status |
|---|---|
| Healthy | |
| Strong | |
| Healthy | |
| Strong |
VRTX's revenue, profitability, cash flow and balance sheet are all currently healthy.
LLY PE Valuation
| Level | PE | Price | Vs current |
|---|---|---|---|
| Cheap | 27x | $845 | -41% |
| Forward | 30x | $1,427 | — |
| Current | 46x | $1,427 | — |
| Fair | 48x | $1,466 | +2.7% |
| Expensive | 85x | $2,612 | +83% |
Historical ranges are pointers, not guarantees.
LLY's PE is in its fair range at 46x. If earnings grow as analysts expect, today's price would be 30x next year's earnings, in its cheap range.
VRTX PE Valuation
| Level | PE | Price | Vs current |
|---|---|---|---|
| Cheap | 23x | $360 | -34% |
| Fair | 28x | $429 | -21% |
| Forward | 29x | $543 | — |
| Expensive | 32x | $496 | -8.7% |
| Current | 35x | $543 | — |
Historical ranges are pointers, not guarantees.
VRTX has the edge over LLY in the historical PE scenario, which offers more potential upside but is not a forecast.
LLY Forward outlook
| Metric | Outlook |
|---|---|
| Strongly improving | |
| Strong growth | |
| Strong growth | |
| Strongly improving | |
| Limited | |
| Moderate |
LLY has the edge over VRTX on the outlook, with more favorable earnings and profitability expectations.
VRTX Forward outlook
| Metric | Outlook |
|---|---|
| Improving | |
| Stable | |
| Growth | |
| Strongly weakening | |
| Limited | |
| Low |
Analysts expect VRTX's revenue to grow, but its profitability to weaken. However, they disagree widely on these estimates.
LLY Earnings Per Share
| Quarter | TTM EPS | YoY |
|---|---|---|
| Forward | $46.82 | +52% |
| Q3 2026 | $30.81 | +51% |
| Q2 2026 | $29.80 | +95% |
| Q1 2026 | $28.15 | +129% |
| Q4 2025 | $22.95 | +96% |
| Q3 2025 | $20.44 | +121% |
| Q2 2025 | $15.30 | +88% |
| Q1 2025 | $12.29 | +81% |
| Q4 2024 | $11.71 | +102% |
LLY has the edge over VRTX on earnings, with more consistent year-over-year improvement.
VRTX Earnings Per Share
| Quarter | TTM EPS | YoY |
|---|---|---|
| Forward | $18.81 | +21% |
| Q3 2026 | $15.53 | +8.6% |
| Q2 2026 | $17.17 | +22% |
| Q1 2026 | $16.85 | +$20.65 |
| Q4 2025 | $15.32 | +$17.40 |
| Q3 2025 | $14.30 | +$16.29 |
| Q2 2025 | $14.11 | +$16.14 |
| Q1 2025 | -$3.80 | -125% |
| Q4 2024 | -$2.08 | -115% |
VRTX earned $15.53 per share over the past year, up 8.6% from the year before.
LLY Quarterly Revenue
| Quarter | Revenue | YoY |
|---|---|---|
| Q3 2026 | $24.4B | +39% |
| Q2 2026 | $23B | +48% |
| Q1 2026 | $19.8B | +56% |
| Q4 2025 | $19.3B | +43% |
| Q3 2025 | $17.6B | +54% |
| Q2 2025 | $15.6B | +38% |
| Q1 2025 | $12.7B | +45% |
| Q4 2024 | $13.5B | +45% |
LLY has the edge over VRTX on sales, with stronger typical year-over-year growth.
| Quarter | Margin | YoY |
|---|---|---|
| Q3 2026 | 34% | -6.6 points |
| Q2 2026 | 40% | -3.3 points |
| Q1 2026 | 45% | +18 points |
| Q4 2025 | 43% | +5.6 points |
| Q3 2025 | 41% | +27 points |
| Q2 2025 | 44% | +12 points |
| Q1 2025 | 27% | -1.8 points |
| Q4 2024 | 37% | +10 points |
LLY has the edge over VRTX on profitability, with a higher operating margin.
VRTX Quarterly Revenue
| Quarter | Revenue | YoY |
|---|---|---|
| Q3 2026 | $3.4B | +12% |
| Q2 2026 | $3.3B | +12% |
| Q1 2026 | $3B | +7.8% |
| Q4 2025 | $3.2B | +9.5% |
| Q3 2025 | $3.1B | +11% |
| Q2 2025 | $3B | +12% |
| Q1 2025 | $2.8B | +3% |
| Q4 2024 | $2.9B | +16% |
VRTX's revenue has grown year over year every quarter since late 2020: $3.4B last quarter, up 12% from the same quarter a year ago.
| Quarter | Margin | YoY |
|---|---|---|
| Q3 2026 | 21% | -18 points |
| Q2 2026 | 37% | -1.4 points |
| Q1 2026 | 38% | +15 points |
| Q4 2025 | 38% | +2.6 points |
| Q3 2025 | 39% | -1.7 points |
| Q2 2025 | 39% | +172 points |
| Q1 2025 | 23% | -20 points |
| Q4 2024 | 35% | -4 points |
VRTX's operating margin was 21% last quarter, down 18 points from the same quarter a year ago, near the bottom of its range since 2019.
LLY Free Cash Flow
| Quarter | Free cash flow | YoY |
|---|---|---|
| Q3 2026 | $8.2B | +22% |
| Q2 2026 | $7.8B | +458% |
| Q1 2026 | $3B | +1826% |
| Q4 2025 | $677.9M | -31% |
| Q3 2025 | $6.7B | +186% |
| Q2 2025 | $1.4B | +476% |
| Q1 2025 | $156.1M | -13% |
| Q4 2024 | $977.8M | +$2.4B |
LLY has the edge over VRTX on cash flow, with more consistent year-over-year improvement.
VRTX Free Cash Flow
| Quarter | Free cash flow | YoY |
|---|---|---|
| Q3 2026 | $545.8M | -52% |
| Q2 2026 | $1B | +9.3% |
| Q1 2026 | $1.3B | +66% |
| Q4 2025 | $348.6M | -29% |
| Q3 2025 | $1.1B | -12% |
| Q2 2025 | $927.4M | +$4.8B |
| Q1 2025 | $778.2M | -37% |
| Q4 2024 | $492M | +179% |
VRTX generated $3.2B in free cash flow over the past year, down 4% from the year before.
LLY Total Shares
| Period | Change % | Net change |
|---|---|---|
| Quarterly | 0% | -300K shares |
| 1 year | -0.6% | -5.4M shares |
| 3 years | -0.7% | -6.4M shares |
| 5 years | -1.9% | -17.4M shares |
| Available history | -4.5% | -42.3M shares |
LLY has 893M diluted shares, down 0.6% from a year ago.
| Quarter | Spent |
|---|---|
| Q3 2026 | $377M |
| Q2 2026 | $1.6B |
| Q1 2026 | $2.4B |
| Q4 2025 | $1.5B |
| Q3 2025 | $708.1M |
| Q2 2025 | $692.2M |
| Q1 2025 | $1.2B |
| Q4 2024 | $2.1B |
LLY spent $5.8B buying back its own shares over the past year, up 26% from the year before.
VRTX Total Shares
| Period | Change % | Net change |
|---|---|---|
| Quarterly | 0% | -- |
| 1 year | -0.9% | -2.4M shares |
| 3 years | -2.1% | -5.4M shares |
| 5 years | -1.7% | -4.5M shares |
| Available history | -2.6% | -6.9M shares |
VRTX has the edge over LLY on shareholder dilution, with a more favorable share count trend.
| Quarter | Spent |
|---|---|
| Q3 2026 | $126.7M |
| Q2 2026 | $469.5M |
| Q1 2026 | $336.9M |
| Q4 2025 | $128.4M |
| Q3 2025 | $1.1B |
| Q2 2025 | $391.8M |
| Q1 2025 | $426.1M |
| Q4 2024 | $417.9M |
VRTX spent $1.1B buying back its own shares over the past year, down 54% from the year before.
LLY Net Leverage
| Quarter | Net Leverage | Status |
|---|---|---|
| Q3 2026 | 1.2x | Healthy |
| Q2 2026 | 1.3x | Healthy |
| Q1 2026 | 1.2x | Healthy |
| Q4 2025 | 1.3x | Healthy |
| Q3 2025 | 1.3x | Healthy |
| Q2 2025 | 2.0x | Healthy |
| Q1 2025 | 2.3x | Moderate |
| Q4 2024 | 2.1x | Moderate |
LLY's net debt is about 1.2 years of its operating earnings (EBITDA), about the same as a year ago.
VRTX Net Leverage
| Quarter | Net Leverage | Status |
|---|---|---|
| Q3 2026 | -0.1x | Net Cash |
| Q2 2026 | -1.2x | Net Cash |
| Q1 2026 | -1.1x | Net Cash |
| Q4 2025 | -1.2x | Net Cash |
| Q3 2025 | -1.2x | Net Cash |
| Q2 2025 | -1.2x | Net Cash |
| Q1 2024 | -2.1x | Net Cash |
| Q4 2023 | -2.6x | Net Cash |
VRTX has the edge over LLY on leverage, with a lower net debt burden relative to earnings.
LLY Weekly Momentum
| Metric | Value | Status |
|---|---|---|
| RSI | 68.3 | Neutral |
| Stochastic | 84.1 | Overbought |
LLY's weekly RSI is 68 (neutral) and its Stochastic is 84 (overbought).
VRTX Weekly Momentum
| Metric | Value | Status |
|---|---|---|
| RSI | 59.4 | Neutral |
| Stochastic | 81.1 | Overbought |
VRTX's weekly RSI is 59 (neutral) and its Stochastic is 81 (overbought).
LLY PE vs Healthcare Sector
| Metric | LLY | Sector median | Relative |
|---|---|---|---|
| PE | 46x | 26x | 79% above |
| PE % | 48 | 29 | 19 pts above |
LLY is trading at 46x earnings, a 79% premium to the Healthcare sector's median of 26x.
VRTX PE vs Healthcare Sector
| Metric | VRTX | Sector median | Relative |
|---|---|---|---|
| PE | 35x | 26x | 35% above |
| PE % | 91 | 29 | 62 pts above |
VRTX has the edge over LLY on valuation relative to its sector.
LLY Weekly Moving Averages
| Moving average | MA price | Relative |
|---|---|---|
| 8 week MA | $1,279.4 | 12% above |
| 20 week MA | $1,218.8 | 17% above |
| 50 week MA | $1,102.2 | 29% above |
| 100 week MA | $954.1 | 50% above |
| 200 week MA | $797.5 | 79% above |
LLY is in an uptrend: it's above all five of its weekly moving averages, and 79% above its 200-week average.
VRTX Weekly Moving Averages
| Moving average | MA price | Relative |
|---|---|---|
| 8 week MA | $526.7 | 3% above |
| 20 week MA | $516.4 | 5.1% above |
| 50 week MA | $479.2 | 13% above |
| 100 week MA | $459.7 | 18% above |
| 200 week MA | $428.4 | 27% above |
VRTX is in an uptrend: it's above all five of its weekly moving averages, and 27% above its 200-week average.
LLY Yearly ROI
| Year | Start price | End price | ROI |
|---|---|---|---|
| 2020 | $131.5 | $166.7 | +27% |
| 2021 | $166.7 | $273.1 | +64% |
| 2022 | $273.1 | $367.9 | +35% |
| 2023 | $367.9 | $582.9 | +58% |
| 2024 | $582.9 | $783.2 | +34% |
| 2025 | $783.2 | $1,077.8 | +38% |
| 2026 YTD | $1,077.8 | $1,427.3 | +32% |
LLY has the edge over VRTX on returns for 2026, with the stronger performance.
VRTX Yearly ROI
| Year | Start price | End price | ROI |
|---|---|---|---|
| 2020 | $221.0 | $234.5 | +6.1% |
| 2021 | $234.5 | $223.5 | -4.7% |
| 2022 | $223.5 | $289.7 | +30% |
| 2023 | $289.7 | $406.9 | +40% |
| 2024 | $406.9 | $408.8 | +0.5% |
| 2025 | $408.8 | $462.9 | +13% |
| 2026 YTD | $462.9 | $542.6 | +17% |
VRTX has finished higher in five of the last six years. It's up 17% so far in 2026.