AGIO
Agios Pharmaceuticals, Inc.
There isn't enough reported data to score AGIO yet.
NVO
Novo Nordisk A/S
NVO's fundamentals are mixed: it turned 15% of its revenue into free cash flow, but its operating margin fell 3 points to 43%. Its PE isn't a useful guide right now because of how its recent earnings were reported.
AGIO Fundamentals
| Metric | Status |
|---|---|
| Strong | |
| Under pressure | |
| Under pressure | |
| Unavailable |
AGIO's revenue is currently strong, but its profitability and cash flow are under pressure. There isn't enough data to rate its balance sheet.
NVO Fundamentals
| Metric | Status |
|---|---|
| Healthy | |
| Strong | |
| Stable | |
| Healthy |
NVO's revenue, profitability and balance sheet are currently healthy, and its cash flow is stable.
AGIO PE Valuation
AGIO has no meaningful PE right now: it lost money over the past year.
NVO PE Valuation
| Level | PE | Price | Vs current |
|---|---|---|---|
| Current | 10x | $40.65 | — |
| Cheap | 14x | $53.56 | +32% |
| Fair | 27x | $103 | +154% |
| Expensive | 39x | $152 | +273% |
Historical ranges are pointers, not guarantees.
NVO's PE is 10x, but its earnings don't support one, so it isn't a reliable read right now.
AGIO Forward outlook
| Metric | Outlook |
|---|---|
| -- | |
| Losses shrinking | |
| Strong growth | |
| -- | |
| Limited | |
| Low |
Analysts expect AGIO's losses to shrink, with revenue growing. However, they disagree widely on these estimates.
NVO Forward outlook
| Metric | Outlook |
|---|---|
| -- | |
| Stable | |
| Growth | |
| Weakening | |
| Limited | |
| Low |
Analysts expect NVO's revenue to grow, but its profitability to weaken. However, they disagree widely on these estimates.
AGIO Earnings Per Share
| Quarter | TTM EPS | YoY |
|---|---|---|
| Q3 2026 | -$6.33 | +$0.37 |
| Q2 2026 | -$7.02 | -162% |
| Q1 2026 | -$7.26 | -163% |
| Q4 2025 | -$7.12 | -161% |
| Q3 2025 | -$6.70 | -159% |
| Q2 2025 | $11.30 | +$17.79 |
| Q1 2025 | $11.54 | +$17.85 |
| Q4 2024 | $11.64 | +$17.97 |
AGIO lost $6.33 per share over the past year, about the same as its loss the year before.
NVO Earnings Per Share
| Quarter | TTM EPS | YoY |
|---|---|---|
| Q2 2026 | $3.89 | +4.9% |
| Q1 2026 | $4.07 | +17% |
| Q4 2025 | $3.42 | +1.8% |
| Q3 2025 | $3.47 | +10% |
| Q2 2025 | $3.71 | +24% |
| Q1 2025 | $3.49 | +18% |
| Q4 2024 | $3.36 | +21% |
| Q3 2024 | $3.15 | +27% |
NVO has the edge over AGIO on earnings quality, reporting a profit while its opponent remains loss making.
AGIO Quarterly Revenue
| Quarter | Revenue | YoY |
|---|---|---|
| Q3 2026 | $55.4M | +330% |
| Q2 2026 | $44.7M | +259% |
| Q1 2026 | $20.7M | +138% |
| Q4 2025 | $20M | +86% |
| Q3 2025 | $12.9M | +44% |
| Q2 2025 | $12.5M | +45% |
| Q1 2025 | $8.7M | +6.6% |
| Q4 2024 | $10.7M | +51% |
AGIO has the edge over NVO on sales, with more consistent year-over-year improvement.
| Quarter | Margin | YoY |
|---|---|---|
| Q3 2026 | -139% | +768 points |
| Q2 2026 | -247% | +773 points |
| Q1 2026 | -530% | +692 points |
| Q4 2025 | -609% | +556 points |
| Q3 2025 | -907% | +240 points |
| Q2 2025 | -1020% | +208 points |
| Q1 2025 | -1222% | -98 points |
| Q4 2024 | -1165% | +331 points |
AGIO's operating margin was −139% last quarter, up 768 points from the same quarter a year ago, near the top of its range since 2019.
NVO Quarterly Revenue
| Quarter | Revenue | YoY |
|---|---|---|
| Q2 2026 | $11.7B | +2.1% |
| Q1 2026 | $14.4B | +24% |
| Q4 2025 | $11.8B | -7.6% |
| Q3 2025 | $11.1B | +5.1% |
| Q2 2025 | $11.4B | +13% |
| Q1 2025 | $11.6B | +19% |
| Q4 2024 | $12.7B | +30% |
| Q3 2024 | $10.6B | +21% |
NVO's revenue is growing: $11.7B last quarter, up 2.1% from the same quarter a year ago.
| Quarter | Margin | YoY |
|---|---|---|
| Q2 2026 | 34% | -9 points |
| Q1 2026 | 62% | +12 points |
| Q4 2025 | 40% | -2.8 points |
| Q3 2025 | 32% | -16 points |
| Q2 2025 | 44% | +5.4 points |
| Q1 2025 | 50% | +1 points |
| Q4 2024 | 43% | +2.2 points |
| Q3 2024 | 47% | +1.6 points |
NVO has the edge over AGIO on profitability, with a higher operating margin.
AGIO Free Cash Flow
| Quarter | Free cash flow | YoY |
|---|---|---|
| Q3 2026 | -$60.4M | +$29.3M |
| Q2 2026 | -$58.5M | +$19.5M |
| Q1 2026 | -$119.7M | -$7.4M |
| Q4 2025 | -$97.3M | +$36.8M |
| Q3 2025 | -$89.7M | -$5.1M |
| Q2 2025 | -$78M | -$5.3M |
| Q1 2025 | -$112.3M | -$12.2M |
| Q4 2024 | -$134.1M | -$61.4M |
AGIO has burned cash in almost every quarter: −$336M over the past year, against −$414M the year before.
NVO Free Cash Flow
| Quarter | Free cash flow | YoY |
|---|---|---|
| Q2 2026 | $6.3B | +73% |
| Q1 2026 | $1.8B | +20% |
| Q4 2025 | -$5.4B | -$4.7B |
| Q3 2025 | $4.6B | -2.1% |
| Q2 2025 | $3.6B | -34% |
| Q1 2025 | $1.5B | +89% |
| Q4 2024 | -$632.6M | +$390.5M |
| Q3 2024 | $4.7B | +3.3% |
NVO has the edge over AGIO on cash generation, producing positive trailing cash flow while its opponent burns cash.
AGIO Total Shares
| Period | Change % | Net change |
|---|---|---|
| Quarterly | +0.4% | +219K shares |
| 1 year | +2.7% | +1.6M shares |
| 3 years | +7% | +3.9M shares |
| 5 years | +4.7% | +2.7M shares |
| Available history | -0.5% | -287K shares |
AGIO has 60M diluted shares, up 2.7% from a year ago.
| Quarter | Spent |
|---|---|
| Q4 2022 | — |
| Q3 2022 | — |
| Q4 2021 | $19M |
| Q3 2021 | $254.4M |
NVO Total Shares
| Period | Change % | Net change |
|---|---|---|
| Quarterly | -0.3% | -12.9M shares |
| 1 year | -0.2% | -11M shares |
| 3 years | -1.5% | -66.8M shares |
| 5 years | -3.8% | -177M shares |
| Available history | -6.5% | -311M shares |
NVO has the edge over AGIO on shareholder dilution, with a more favorable share count trend.
| Quarter | Spent |
|---|---|
| Q2 2026 | $520M |
| Q1 2026 | $356.7M |
| Q4 2025 | — |
| Q3 2025 | — |
| Q2 2025 | — |
| Q1 2025 | $206.3M |
| Q4 2024 | $1.1B |
| Q3 2024 | $357.4M |
NVO spent $877M buying back its own shares over the past year, down 48% from the year before.
AGIO Net Leverage
AGIO's operating earnings (EBITDA) were negative over the past year, so its debt can't be measured against them.
NVO Net Leverage
| Quarter | Net Leverage | Status |
|---|---|---|
| Q2 2026 | 0.5x | Very low |
| Q1 2026 | 0.7x | Very low |
| Q4 2025 | 0.6x | Very low |
| Q3 2025 | 0.4x | Very low |
| Q2 2025 | 0.5x | Very low |
| Q1 2025 | 0.5x | Very low |
| Q4 2024 | 0.6x | Very low |
| Q3 2024 | -0.0x | Very low |
NVO's net debt is less than a year of its operating earnings (EBITDA).
AGIO Weekly Momentum
| Metric | Value | Status |
|---|---|---|
| RSI | 48.7 | Neutral |
| Stochastic | 23.0 | Neutral |
AGIO's weekly RSI is 49 (neutral) and its Stochastic is 23 (neutral).
NVO Weekly Momentum
| Metric | Value | Status |
|---|---|---|
| RSI | 43.0 | Neutral |
| Stochastic | 27.0 | Neutral |
NVO's weekly RSI is 43 (neutral) and its Stochastic is 27 (neutral).
AGIO PE vs Healthcare Sector
| Metric | AGIO | Sector median | Relative |
|---|---|---|---|
| PE | N/A | 26x | — |
AGIO has no meaningful PE right now: it lost money over the past year.
NVO PE vs Healthcare Sector
| Metric | NVO | Sector median | Relative |
|---|---|---|---|
| PE | 10x | 26x | 60% below |
| PE % | 6 | 29 | 23 pts below |
NVO is trading at 10x earnings, a 60% discount to the Healthcare sector's median of 26x, though its earnings don't support one.
AGIO Weekly Moving Averages
| Moving average | MA price | Relative |
|---|---|---|
| 8 week MA | $32.0 | 0.8% below |
| 20 week MA | $33.7 | 5.6% below |
| 50 week MA | $30.9 | 2.7% above |
| 100 week MA | $32.8 | 3.1% below |
| 200 week MA | $32.4 | 1.9% below |
AGIO's trend is mixed: it's above one of its five weekly moving averages, and 1.9% below its 200-week average.
NVO Weekly Moving Averages
| Moving average | MA price | Relative |
|---|---|---|
| 8 week MA | $39.2 | 3.7% above |
| 20 week MA | $43.9 | 7.4% below |
| 50 week MA | $45.3 | 10% below |
| 100 week MA | $56.3 | 28% below |
| 200 week MA | $80.7 | 50% below |
NVO has bounced recently, but its long-term trend is still down: it's above its 8-week average, but 50% below its 200-week average.
AGIO Yearly ROI
| Year | Start price | End price | ROI |
|---|---|---|---|
| 2020 | $48.5 | $45.2 | -6.9% |
| 2021 | $45.2 | $35.8 | -21% |
| 2022 | $35.8 | $27.0 | -25% |
| 2023 | $27.0 | $22.3 | -18% |
| 2024 | $22.3 | $33.4 | +50% |
| 2025 | $33.4 | $28.0 | -16% |
| 2026 YTD | $28.0 | $31.8 | +13% |
AGIO has the edge over NVO on returns for 2026, with the stronger performance.
NVO Yearly ROI
| Year | Start price | End price | ROI |
|---|---|---|---|
| 2020 | $29.1 | $34.7 | +19% |
| 2021 | $34.7 | $54.2 | +56% |
| 2022 | $54.2 | $67.0 | +24% |
| 2023 | $67.0 | $103.5 | +54% |
| 2024 | $103.5 | $87.4 | -16% |
| 2025 | $87.4 | $52.4 | -40% |
| 2026 YTD | $52.4 | $40.7 | -22% |
NVO has finished higher in four of the last six years, two of them by more than 50%. It's down 22% so far in 2026.